Adriaenssens A, Broichhagen J, de Bray A, Ast J, Hasib A, Jones B, Tomas A, Figueredo Burgos N, Woodward O, Lewis J, O’Flaherty E, El K, Cui C, Harada N, Inagaki N, Campbell J, Brierley DI, Hodson D, Samms R, Gribble F, and Reimann F. Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding. JCI Insight (2023) 8:e164921 

[Wagner S, Brierley DI]^1st, Leeson-Payne A, Jiang W, Chianese R, Lam B, Dowsett G, Christiano C, Lyons D, Leeson-Payne A, Reimann F, Gribble FM, Martinez de Morentin P, Yeo GSH, Trapp S, Heisler LK. Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression. Molecular Metabolism (2023) 68:101665 

Trapp S and Brierley DI. Brain GLP-1 and the regulation of food intake: the physiology of GLP-1 action in the brain and its implications for pharmacological obesity treatment. British Journal of Pharmacology (2021) 179:557-570

Brierley DI and de Lartigue G. Reappraising the role of the vagus nerve in GLP-1-mediated regulation of eating. British Journal of Pharmacology (2021) 179:584-599

Brierley DI, Holt MK, Singh A, de Araujo A, Vergara M, Afaghani MH, Lee SJ, Scott K, Maske C, Langhans W, Krause E, de Kloet A, Gribble FM, Reimann F, Rinaman L, de Lartigue G, Trapp S. Central and peripheral GLP-1 systems independently suppress eating. Nature Metabolism (2021) 3:258-273

Holt MK, Cook DR, Brierley DI, Richards JE, Reimann F, Gourine AV,  Marina N, Trapp, S. PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice. Molecular Metabolism (2020) 39:101024

Ast J, Arvaniti A, Fine N, Nasteska D, Ashford F, Stamataki Z, Koszegi Z, Bacon A, Jones B, Lucey M, Sasaki S, Brierley DI, Hastoy B, Tomas A, D’Agostino G, Reimann F, Lynn F, Reissaus C, Linnemann A, D’Este E, Calebiro D, Trapp S, Johnsson K, Podewin T, Broichhagen J, Hodson D. Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics. Nature Communications (2020) 11:467

Brierley DI, Harman JR, Giallourou N, Leishman E, Roashan AE, Mellows BA, Bradshaw HB, Swann JR, Patel K, Whalley BJ, Williams CM. Chemotherapy-induced cachexia dysregulates hypothalamic and systemic lipoamines and is attenuated by cannabigerol. Journal of Cachexia Sarcopenia and Muscle (2019) 10(4):844-859

Holt MK, Richards JE, Cook DR, Brierley DI, Williams DL, Reimann F, Gribble FM, Trapp S. Preproglucagon Neurons in the Nucleus of the Solitary Tract are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes (2019) 68(1):21-33

Card JP, Johnson AL, Llewellyn-Smith IJ, Zheng H, Anand R, Brierley DI, Trapp S, Rinaman L. GLP-1 neurons form a local synaptic circuit within the rodent nucleus of the solitary tract. Journal of Comparative Neurology (2018) 526(14):2149-2164

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. A cannabigerol-rich Cannabis sativa extract, devoid of Δ⁹-tetrahydrocannabinol, elicits hyperphagia in rats. Behavioural Pharmacology (2017) 28(4):280-284

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology (2016) 233(19-20):3603-13

Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea. Psychopharmacology (2016) 233(2):243-54

Brierley DI & Davidson C. Harmine augments electrically evoked dopamine efflux in the nucleus accumbens shell. The Journal of Psychopharmacology (2013) 27(1):98-108

Brierley DI & Davidson C. Developments in harmine pharmacology – implications for ayahuasca use and drug-dependence treatment. Progress in Neuro-Psychopharmacology & Biological Psychiatry (2012) 39(2):263-272

Brischoux F, Chakraborty S, Brierley DI, Ungless MA. Phasic excitation of dopamine neurons in ventral VTA by noxious stimuli. Proceedings of the National Academy of Sciences of the United States of America (2009) 106(12):4894-9